US National Security Adviser John Bolton was deployed to Israel to allay concerns about President Donald Trump's decision to withdrawal troops from Syria and discuss the process with Turkish officials.
The pull-out announced last month was initially expected to be completed within weeks, but the timetable has slowed as the president acceded to requests from aides, allies and members of US Congress for a more orderly drawdown.
Bolton plans to meet Israel's prime minister, Benjamin Netanyahu, and other officials on Sunday before travelling to Turkey.
Israeli officials have expressed concern that a swift withdrawal of the roughly 2 000 troops could enable Iran to expand its influence and presence in war-torn Syria.
"There is a great concern among US allies in the region about what is the next step," said Yossi Mekelberg, professor of international relations at Regent's University London.
"The Trump administration's message is completely incoherent. On the one hand, the Trump administration is talking about more pressure on Iran vis-a-vis the nuclear issue. But the withdrawal leaves Syria open to Russia and Iran," he said.
Trump's move has also raised fears about clearing the way for a Turkish assault on Kurdish fighters in Syria who have fought alongside American troops against Islamic State of Iraq and the Levant (ISIL).
Turkey considers the Kurdish People's Protection Units (YPG) a "terrorist" group linked to Kurdish fighters within its own borders.
"Top on Turkey's list is the disarmament of the Kurdish YPG fighters," said Al Jazeera's Mohammed Adow, reporting from Gaziantep on Turkey's border with Syria.
"Turkey wants them disarmed and removed from the areas near its border with Syria. Turkey also wants logistical and air support from the US, once the troop withdrawal is complete. Turkish officials will want John Bolton to come up with a clear timetable for withdrawal.
Bolton also warned Syria's president, Bashar Assad, not to use the US withdrawal as a pretext to use chemical weapons against Syrians, saying there is "no change" to the US position that their use is a "red line".
Trump has twice carried out air strikes in Syria in response to alleged chemical attacks with the intention of deterring Assad.
Secretary of State Mike Pompeo is following Bolton to the Middle East this coming week for an eight-country tour of Arab allies to shore up support for the administration's partners in the region.
The chair of the US Joint Chiefs of Staff General Joseph Dunford will join Bolton in Turkey.
In meetings with Turkey's President Recep Tayyip Erdogan and other officials they are expected to warn against an offensive targeting the Kurdish fighters in Syria.