Two people lost their lives and two more were injured when two trucks and two passenger cars crashed on the R21 between Pretoria and Kempton Park on Friday night.
The incident happened at around 22:00, Netcare 911 spokesperson Shawn Herbst said.
"Netcare 911 responded to reports of a serious collision on the R21 travelling from Pretoria to Kempton Park.
"Reports from the scene indicate that two heavy motor vehicles and a light motor vehicle were involved in a collision.
"Two people tragically sustained fatal injuries and were declared deceased on the scene.
"Another two patients were assessed and found to have sustained minor injuries.
"Both patients were treated on [the] scene and transported by another ambulance service to hospital for further assessment.